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Uncontrolled muscle biopsy studies enrolling patients with T2DM show that 12 weeks of pioglitazone 30 mg once daily improved skeletal muscle mitochondrial respiration measured by high-resolution respirometry of muscle biopsies, whereas 12 weeks of rosiglitazone 4 mg once daily worsened mitochondrial respiration [123]

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We cannot prevent or predict every interaction, and the science is clear that most exposureseven common onesonly raise risk slightly

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, 2015), which could regulate the binding affinity of APX1 for ascorbate, resulting in increased PRX activity

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