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and one presently under FDA review for the same (tirzepatide or Mounjaro)

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This severe depletion of GSH results in the synthesis of large amounts of -glutamylcysteine, which is increasingly converted to pyroglutamate when glycine is depleted, leading to metabolic acidosis

24 ChevalierC.ThibergeJ.FerreroR

[DOI] [PubMed] [Google Scholar] 114.Pascual M, Castilla-Cortazar I, Urdaneta E, Quiroga J, Garcia M, Picardi A, Prieto J