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Week 13-24: Major transformation Physical changes: 25-40 pounds total weight loss (highly variable based on starting weight) Dramatic body shape changes Features previously hidden by fat now visible (cheekbones, jawline, abs) Size dropped significantly (2-4 clothing sizes) What photos show: This looks like a different person

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Another example of precursor use involves L-2-oxothiazofidine-4-carboxylate, which is converted to S-carboxyl-L-cysteine and undergoes spontaneous decarboxy-lation to liberate L-Cysteine, thereby supporting GSH synthesis

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The prodrug 4-chlorokynurenine causes ketamine-like antidepressant effects, but not side effects, by NMDA/glycineB-site inhibition